Understanding the Role of Methionine Oxidation in Amyloid Formation

Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1

V Muleya, C Marondedze, JI Wheeler, L Thomas, YF Mok, MDW Griffin, DT Manallack, L Kwezi, KS Lilley, C Gehring, HR Irving

2016-01-01

Phytosulfokines (PSKs) are plant peptide hormones that co-regulate plant growth, differentiation and defense responses. PSKs signa..

Fluphenazine·HCl and Epigallocatechin Gallate Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

CO Zlatic, Y Mao, TM Ryan, YF Mok, BR Roberts, GJ Howlett, MDW Griffin

2015-06-23

Protein misfolding and aggregation, leading to amyloid fibril formation, are characteristic of many devastating and debilitating a..

Charge and charge-pair mutations alter the rate of assembly and structural properties of apolipoprotein C-II amyloid fibrils

Y Mao, CL Teoh, S Yang, CO Zlatic, ZK Rosenes, PR Gooley, GJ Howlett, MDW Griffin

2015-02-17

The misfolding, aggregation, and accumulation of proteins as amyloid fibrils is a defining characteristic of several debilitating ..

The role of lipid in misfolding and amyloid fibril formation by apolipoprotein C-II

TM Ryan, YF Mok, GJ Howlett, MDW Griffin

2015-01-01

Apolipoproteins are a key component of lipid transport in the circulatory system and share a number of structural features that fa..

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

TL Putoczki, RCJ Dobson, MDW Griffin

2014-08-26

Interleukin (IL)-11 is a multifunctional member of the IL-6 family of cytokines. Recombinant human IL-11 is administered as a stan..

Small oligomers of ribulose-bisphosphate carboxylase/oxygenase (Rubisco) activase are required for biological activity

JR Keown, MDW Griffin, HDT Mertens, FG Pearce

2013-07-12

Ribulose-bisphosphate carboxylase/oxygenase (Rubisco) activase uses the energy from ATP hydrolysis to remove tight binding inhibit..

Avoiding the oligomeric state: αB-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils

KJ Binger, H Ecroyd, S Yang, JA Carver, GJ Howlett, MDW Griffin

2013-03-01

The in vivo aggregation of proteins into amyloid fibrils suggests that cellular mechanisms that normally prevent or reverse this a..

Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus

RA North, SA Kessans, SC Atkinson, H Suzuki, AJA Watson, BR Burgess, LM Angley, AO Hudson, A Varsani, MDW Griffin, AJ Fairbanks, RCJ Dobson

2013-03-01

The enzyme N-acetylneuraminate lyase (EC 4.1.3.3) is involved in the metabolism of sialic acids. Specifically, the enzyme catalyze..

An equilibrium model for linear and closed-loop amyloid fibril formation

S Yang, MDW Griffin, KJ Binger, P Schuck, GJ Howlett

2012-08-10

Amyloid fibrils and their soluble oligomeric intermediates are implicated in several age-related diseases including Alzheimer's an..

A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin

M Radjainia, B Huang, B Bai, M Schmitz, SH Yang, PWR Harris, MDW Griffin, MA Brimble, Y Wang, AK Mitra

2012-07-01

Adiponectin is a collagenous adipokine with direct anti-diabetic and anti-atherogenic properties. It can assume an ensemble of oli..

Identification of an amyloid fibril forming peptide comprising residues 46-59 of apolipoprotein A-I

YQ Wong, KJ Binger, GJ Howlett, MDW Griffin

2012-06-21

Apolipoprotein A-I (apoA-I) is deposited as amyloid within various major organs in hereditary apoA-I amyloidosis, and in arterial ..

A cyclic peptide inhibitor of ApoC-II peptide fibril formation: Mechanistic insight from NMR and molecular dynamics analysis

MDW Griffin, L Yeung, A Hung, N Todorova, YF Mok, JA Karas, PR Gooley, I Yarovsky, GJ Howlett

2012-03-09

The misfolding and aggregation of proteins to form amyloid fibrils is a characteristic feature of several common age-related disea..

NBD-labeled phospholipid accelerates apolipoprotein C-II amyloid fibril formation but is not incorporated into mature fibrils

TM Ryan, MDW Griffin, MF Bailey, P Schuck, GJ Howlett

2011-11-08

Human apolipoprotein (apo) C-II is one of several lipid-binding proteins that self-assemble into fibrils and accumulate in disease..

Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana

MDW Griffin, JM Billakanti, JA Gerrard, RCJ Dobson, FG Pearce

2011-11-01

Dihydrodipicolinate synthase (DHDPS; EC 4.2.1.52) catalyzes the first committed step of the lysine-biosynthetic pathway in plants ..

A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis

G Evans, L Schuldt, MDW Griffin, SRA Devenish, F Grant Pearce, MA Perugini, RCJ Dobson, GB Jameson, MS Weiss, JA Gerrard

2011-08-15

Dihydrodipicolinate synthase (DHDPS) is a validated antibiotic target for which a new approach to inhibitor design has been propos..